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School of Medicine
BRAIN

Publications

Pediatric Disorders - ADHD

  • Stanley JA, Kipp H, Greisenegger E, MacMaster FP, Panchalingam K, Pettegrew JW, Keshavan MS and Bukstein OG. Regionally specific alterations in membrane phospholipids in children with ADHD: An in vivo 31P spectroscopy study. Psychiatry research, 148:217-21, 2006.
  • Stanley JA, Kipp H, Greisenegger E, Macmaster FP, Panchalingam K, Keshavan MS, Bukstein OG and Pettegrew JW. Evidence of developmental alterations in cortical and subcortical regions of children with attention-deficit/hyperactivity disorder: a multivoxel in vivo phosphorus 31 spectroscopy study. Arch. Gen. Psychiatry, 65:1419-28, 2008.

Pediatric Disorders – Obsessive Compulsive Disorder

  • Macmaster FP, Russell A, Mirza Y, Keshavan MS, Banerjee SP, Bhandari R, Boyd C, Lynch M, Rose M, Ivey J, Moore GJ and Rosenberg DR. Pituitary volume in pediatric obsessive-compulsive disorder. Biol. Psychiatry, 59:252-7, 2006.
  • Gilbert AR, Keshavan MS, Diwadkar V, Nutche J, Macmaster F, Easter PC, Buhagiar CJ and Rosenberg DR. Gray matter differences between pediatric obsessive-compulsive disorder patients and high-risk siblings: a preliminary voxel-based morphometry study. Neurosci. Lett., 435:45-50, 2008.
  • Gilbert AR, Mataix-Cols D, Almeida JR, Lawrence N, Nutche J, Diwadkar V, Keshavan MS and Phillips ML. Brain structure and symptom dimension relationships in obsessive-compulsive disorder: a voxel-based morphometry study. Journal of affective disorders, 109:117-26, 2008.
  • Szeszko PR, Christian C, Macmaster F, Lencz T, Mirza Y, Taormina SP, Easter P, Rose M, Michalopoulou GA and Rosenberg DR. Gray matter structural alterations in psychotropic drug-naive pediatric obsessive-compulsive disorder: an optimized voxel-based morphometry study. The American journal of psychiatry, 165:1299-307, 2008.
  • Macmaster FP, O'Neill J and Rosenberg DR. Brain Imaging in Pediatric Obsessive-Compulsive Disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 2008. [Paper]

Pediatric Disorders – Mood Disorders

  • Caetano SC, Fonseca M, Olvera RL, Nicoletti M, Hatch JP, Stanley JA, Hunter K, Lafer B, Pliszka SR and Soares JC. Proton spectroscopy study of the left dorsolateral prefrontal cortex in pediatric depressed patients. Neurosci. Lett., 384:321-6, 2005. [Paper]
  • Rosenberg DR, Macmaster FP, Mirza Y, Smith JM, Easter PC, Banerjee SP, Bhandari R, Boyd C, Lynch M, Rose M, Ivey J, Villafuerte RA, Moore GJ and Renshaw P. Reduced anterior cingulate glutamate in pediatric major depression: a magnetic resonance spectroscopy study. Biol. Psychiatry, 58:700-4, 2005.
  • Sassi RB, Stanley JA, Axelson D, Brambilla P, Nicoletti MA, Keshavan MS, Ramos RT, Ryan N, Birmaher B and Soares JC. Reduced NAA levels in the dorsolateral prefrontal cortex of young bipolar patients. The American journal of psychiatry, 162:2109-15, 2005.
  • Macmaster FP, Russell A, Mirza Y, Keshavan MS, Taormina SP, Bhandari R, Boyd C, Lynch M, Rose M, Ivey J, Moore GJ and Rosenberg DR. Pituitary volume in treatment-naïve pediatric major depressive disorder. Biol. Psychiatry, 60:862-6, 2006.
  • Macmaster FP, Keshavan M, Mirza Y, Carrey N, Upadhyaya AR, El-Sheikh R, Buhagiar CJ, Taormina SP, Boyd C, Lynch M, Rose M, Ivey J, Moore GJ and Rosenberg DR. Development and sexual dimorphism of the pituitary gland. Life Sci, 80:940-4, 2007.
  • Olvera RL, Caetano SC, Fonseca M, Nicoletti M, Stanley JA, Chen HH, Hatch JP, Hunter K, Pliszka SR and Soares JC. Low levels of N-acetyl aspartate in the left dorsolateral prefrontal cortex of pediatric bipolar patients. Journal of child and adolescent psychopharmacology, 17:461-74, 2007.
  • Macmaster FP, Mirza Y, Szeszko PR, Kmiecik LE, Easter PC, Taormina SP, Lynch M, Rose M, Moore GJ and Rosenberg DR. Amygdala and hippocampal volumes in familial early onset major depressive disorder. Biol. Psychiatry, 63:385-90, 2008.
  • Macmaster FP, Moore GJ, Russell A, Mirza Y, Taormina SP, Buhagiar C and Rosenberg DR. Medial temporal N-acetyl-aspartate in pediatric major depression. Psychiatry research, 164:86-9, 2008.
  • Macmaster FP and Rosenberg DR. Preparing children for MRI. Pediatric radiology, 38:270, 2008.
  • Chen HH, Rosenberg DR, Macmaster FP, Easter PC, Caetano SC, Nicoletti M, Hatch JP, Nery FG and Soares JC. Orbitofrontal cortex volumes in medication naïve children with major depressive disorder: a magnetic resonance imaging study. Journal of child and adolescent psychopharmacology, 18:551-6, 2008. [Paper]
  • Matsuo K, Rosenberg DR, Easter PC, Macmaster FP, Chen HH, Nicoletti M, Caetano SC, Hatch JP and Soares JC. Striatal volume abnormalities in treatment-naïve patients diagnosed with pediatric major depressive disorder. Journal of child and adolescent psychopharmacology, 18:121-31, 2008.

Other Pediatric Disorders

  • Hardan AY, Minshew NJ, Melhem NM, Srihari S, Jo B, Bansal R, Keshavan MS and Stanley JA. An MRI and proton spectroscopy study of the thalamus in children with autism. Psychiatry research, 163:97-105, 2008.[Paper]

Schizophrenia

  • Rajarethinam R, Sahni S, Rosenberg DR and Keshavan MS. Reduced superior temporal gyrus volume in young offspring of patients with schizophrenia. The American journal of psychiatry, 161:1121-4, 2004.
  • Diwadkar VA, DeBellis MD, Sweeney JA, Pettegrew JW and Keshavan MS. Abnormalities in MRI-measured signal intensity in the corpus callosum in schizophrenia. Schizophr. Res., 67:277-82, 2004.
  • Keshavan MS, Diwadkar VA, Montrose DM, Stanley JA and Pettegrew JW. Premorbid characterization in schizophrenia: the Pittsburgh High Risk Study. World psychiatry : official journal of the World Psychiatric Association (WPA), 3:163-8, 2004. [Paper]
  • Diwadkar VA, Prasad KM and Keshavan MS. Approaches for adolescents with an affected family member with schizophrenia. Current psychiatry reports, 6:296-302, 2004.
  • Keshavan MS, Diwadkar VA, Montrose DM, Rajarethinam R and Sweeney JA. Premorbid indicators and risk for schizophrenia: a selective review and update. Schizophr. Res., 79:45-57, 2005. [Paper]
  • Diwadkar VA, Montrose DM, Dworakowski D, Sweeney JA and Keshavan MS. Genetically predisposed offspring with schizotypal features: an ultra high-risk group for schizophrenia? Prog. Neuropsychopharmacol. Biol. Psychiatry, 30:230-8, 2006.[Paper]
  • Girgis RR, Diwadkar VA, Nutche JJ, Sweeney JA, Keshavan MS and Hardan AY. Risperidone in first-episode psychosis: a longitudinal, exploratory voxel-based morphometric study. Schizophr. Res., 82:89-94, 2006.
  • Yeragani VK, Cashmere D, Miewald J, Tancer M and Keshavan MS. Decreased coherence in higher frequency ranges (beta and gamma) between central and frontal EEG in patients with schizophrenia: A preliminary report. Psychiatry research, 141:53-60, 2006.
  • Keshavan MS, Roberts M and Wittmann D. Guidelines for clinical treatment of early course schizophrenia. Current psychiatry reports, 8:329-34, 2006.
  • Hill SY, Kostelnik B, Holmes B, Goradia D, McDermott M, Diwadkar V and Keshavan M. fMRI BOLD response to the eyes task in offspring from multiplex alcohol dependence families. Alcohol. Clin. Exp. Res., 31:2028-35, 2007.
  • Upadhyaya AR, El-Sheikh R, Macmaster FP, Diwadkar VA and Keshavan MS. Pituitary volume in neuroleptic-naïve schizophrenia: a structural MRI study. Schizophr. Res., 90:266-73, 2007.
  • Macmaster FP, El-Sheikh R, Upadhyaya AR, Nutche J, Rosenberg DR and Keshavan M. Effect of antipsychotics on pituitary gland volume in treatment-naïve first-episode schizophrenia: a pilot study. Schizophr. Res., 92:207-10, 2007.
  • Wittmann D and Keshavan M. Grief and mourning in schizophrenia. Psychiatry, 70:154-66, 2007.
  • Keshavan MS and Amirsadri A. Early intervention in schizophrenia: current and future perspectives. Current psychiatry reports, 9:325-8, 2007.
  • Rajarethinam R, Upadhyaya A, Tsou P, Upadhyaya M and Keshavan MS. Caudate volume in offspring of patients with schizophrenia. The British journal of psychiatry : the journal of mental science, 191:258-9, 2007.
  • Stanley JA, Vemulapalli M, Nutche J, Montrose DM, Sweeney JA, Pettegrew JW, Macmaster FP and Keshavan MS. Reduced N-acetyl-aspartate levels in schizophrenia patients with a younger onset age: A single-voxel (1)H spectroscopy study. Schizophr. Res., 2007.
  • Sundaresan K, Ziemann U, Stanley J and Boutros N. Cortical inhibition and excitation in abstinent cocaine-dependent patients: a transcranial magnetic stimulation study. Neuroreport, 18:289-92, 2007.
  • Keshavan M, Montrose DM, Rajarethinam R, Diwadkar V, Prasad K and Sweeney JA. Psychopathology among offspring of parents with schizophrenia: relationship to premorbid impairments. Schizophr. Res., 103:114-20, 2008a.
  • Bangalore SS, Prasad KM, Montrose DM, Goradia DD, Diwadkar VA and Keshavan MS. Cannabis use and brain structural alterations in first episode schizophrenia--a region of interest, voxel based morphometric study. Schizophr. Res., 99:1-6, 2008.
  • Diwadkar VA, Flaugher B, Jones T, Zalányi L, Ujfalussy B, Keshavan MS and Erdi P. Impaired associative learning in schizophrenia: behavioral and computational studies. Cognitive neurodynamics, 2:207-19, 2008. [Paper]
  • Keshavan MS, Tandon R, Boutros NN and Nasrallah HA. Schizophrenia, "just the facts": what we know in 2008 Part 3: neurobiology. Schizophr. Res., 106:89-107, 2008.
  • Rajarethinam R, Sohi J, Arfken C and Keshavan MS. No difference in the prevalence of cavum septum pellucidum (CSP) between first-episode schizophrenia patients, offspring of schizophrenia patients and healthy controls. Schizophr. Res., 103:22-5, 2008.
  • Prasad KM, Sanders R, Sweeney J, Montrose D, Diwadkar V, Dworakowski D, Miewald J and Keshavan M. Neurological abnormalities among offspring of persons with schizophrenia: Relation to premorbid psychopathology. Schizophr. Res., 2008.

Mood Disorders

  • Brambilla P, Stanley JA, Sassi RB, Nicoletti MA, Mallinger AG, Keshavan MS and Soares JC. 1H MRS study of dorsolateral prefrontal cortex in healthy individuals before and after lithium administration. Neuropsychopharmacology, 29:1918-24, 2004. [Paper]
  • Brambilla P, Stanley JA, Nicoletti MA, Sassi RB, Mallinger AG, Frank E, Kupfer D, Keshavan MS and Soares JC. 1H magnetic resonance spectroscopy investigation of the dorsolateral prefrontal cortex in bipolar disorder patients. Journal of affective disorders, 86:61-7, 2005. [Paper]
  • Brambilla P, Stanley JA, Nicoletti MA, Sassi RB, Mallinger AG, Frank E, Kupfer DJ, Keshavan MS and Soares JC. 1H Magnetic resonance spectroscopy study of dorsolateral prefrontal cortex in unipolar mood disorder patients. Psychiatry research, 138:131-9, 2005. [Paper]
  • Frey BN, Folgierini M, Nicoletti M, Machado-Vieira R, Stanley JA, Soares JC and Kapczinski F. A proton magnetic resonance spectroscopy investigation of the dorsolateral prefrontal cortex in acute mania. Human psychopharmacology, 20:133-9, 2005.
  • Frey BN, Stanley JA, Nery FG, Monkul ES, Nicoletti MA, Chen HH, Hatch JP, Caetano SC, Ortiz O, Kapczinski F and Soares JC. Abnormal cellular energy and phospholipid metabolism in the left dorsolateral prefrontal cortex of medication-free individuals with bipolar disorder: an in vivo 1H MRS study. Bipolar disorders, 9 Suppl 1:119-27, 2007. [Paper]
  • Macmaster FP, Leslie R, Rosenberg DR and Kusumakar V. Pituitary gland volume in adolescent and young adult bipolar and unipolar depression. Bipolar disorders, 10:101-4, 2008.

Other Disorders

  • Soloff P, Nutche J, Goradia D and Diwadkar V. Structural brain abnormalities in borderline personality disorder: a voxel-based morphometry study. Psychiatry research, 164:223-36, 2008.

Pre-Clinical Research

  • Colen CB, Seraji-Bozorgzad N, Marples B, Galloway MP, Sloan AE and Mathupala SP. Metabolic remodeling of malignant gliomas for enhanced sensitization during radiotherapy: an in vitro study. Neurosurgery, 59:1313-23; discussion 23-4, 2006.
  • O'Leary-Moore SK, Galloway MP, McMechan AP, Hannigan JH and Bowen SE. Region-dependent alterations in glutamate and GABA measured by high-resolution magnetic resonance spectroscopy following acute binge inhalation of toluene in juvenile rats. Neurotoxicology and teratology, 29:466-75, 2007.
  • O'leary-Moore SK, Mcmechan A, Galloway MP and Hannigan JH. Neonatal alcohol-induced region-dependent changes in rat brain neurochemistry measured by high-resolution magnetic resonance spectroscopy. Alcohol. Clin. Exp. Res., 32:1697-707, 2008.
  • Perrine SA, Michaels MS, Ghoddoussi F, Hyde EM, Tancer ME and Galloway MP. Cardiac effects of MDMA on the metabolic profile determined with (1)H-magnetic resonance spectroscopy in the rat. NMR in biomedicine, 2008